Inspiring the Future through Neuroscience
The 25th Annual Meeting of the Korean Society for Brain and Neural Sciences2022. 5. 19 (Thu) ~ 5. 21 (Sat)
2022. 5. 19 (Thu) ~ 5. 21 (Sat)
Cheil Moon (Daegu Gyeongbuk Institute of Science and Technology)
Eun Jeong Lee (Ajou University)
ModeratorCheil Moon (Daegu Gyeongbuk Institute of Science and Technology)
The chemical senses have been spotlighted since Drs. Axel and Buck were awarded the Noble Prize in 2004 due to their pioneer works identifying odorant receptors and olfactory processes. The olfactory system responsible for the chemical senses detects chemicals from the environment using odorant receptors in the olfactory epithelium, encodes the signals in the olfactory bulb, and then processes the encoded signals in the brain. Numbers of interdisciplinary studies have recently been developed to answer intriguing questions regarding interactions between chemicals and their odorant receptors, circuits for the brain`s signal processing, and the cognitive changes by olfactory stimulation. In this symposium, four experts in the field of olfaction will discuss the recent research trends of the olfactory system and present future research directions.
Time | Speaker | Affiliation | Title |
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14:20-14:45 | Jerome Golebiowski | Universite Cote d’Azur | From a molecule to an odor |
14:45-15:10 | Daniel Wesson | University of Florida | Mechanisms underlying the ability of rodents to display selective attention to odors |
15:10-15:35 | Eun Jeong Lee | Ajou University | Odor blocking of stress |
15:35-16:00 | Cheil Moon | Daegu Gyeongbuk Institute of Science and Technology | Neuropathology of the olfactory system in Alzheimer’s disease |
Young Bin Hong (Dong-A University)
ModeratorSeog Bae Oh (Seoul National University)
Supported by Dong-A University Peripheral Neuropathy Research Center
Peripheral neuropathy is caused by the degeneration of peripheral axon and myelinating Schwann cells. Compared to neurodegeneration in the central nervous system, the pathological features and treatment efforts have received less attention. This symposium, held jointly by the Peripheral Neuropathy Research Center (PNRC) in Dong-A university, aims to bring together recent advances in our understanding of key pathologic features of the disease and efforts to facilitate the translation of novel therapies into the clinic.
Time | Speaker | Affiliation | Title |
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14:20-14:45 | Hwan Tae Park | Dong-A University | Myelin-derived secretory phagophore mediates myelin discharge by Schwann cells in peripheral demyelination |
14:45-15:10 | Toshiyuki Araki | National Center of Neurology and Psychiatry | Axonal degeneration mechanism as a therapeutic target for neurological diseases |
15:10-15:35 | Gabsang Lee | Johns Hopkins University | Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder |
15:35-16:00 | Young Bin Hong | Dong-A University | Roles of cytokines in the pathogenesis of demyelinating Schwann cells |
Jong Cheol Rah (Korea Brain Research Institute)
Jeongyeon Kim (Korea Brain Research Institute)
ModeratorJong Cheol Rah (Korea Brain Research Institute)
Jeongyeon Kim (Korea Brain Research Institute)
Supported by Korea Brain Research Institute
Supported by Neurorive Inc.
The field of neuroscience now has embraced emotion in a social context which has been challenged in psychology and psychiatry as a key question. Much of the progress has come from behavioral studies of how social information is regulated with emotional state from rodent to human levels.
Time | Speaker | Affiliation | Title |
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14:20-14:45 | Hirotaka Kosaka | University of Fukui | Neuroimaging researches in adults with autism spectrum disorders |
14:45-15:10 | Ja Wook Koo | Korea Brain Research Institute | Metabotropic glutamate receptor 5 in amygdala target neurons regulates susceptibility to chronic social stress |
15:10-15:35 | Jung-Seok Choi | Samsung Medical Center | Neurophysiological researches in behavioral addiction |
15:35-16:00 | Sehoon Keum | Institute for Basic Science | Neural circuit mechanisms for affective empathy |
Jinju Han (Korea Advanced Institute of Science and Technology)
Hosung Jung (Yonsei University)
ModeratorJinju Han (Korea Advanced Institute of Science and Technology)
Hosung Jung (Yonsei University)
To understand human nervous system development, many model systems have been established. However, it has now become clear that some aspects of human development are uniquely human and cannot be modeled using other animals. Over the past decade, approaches to modeling nervous system development based on human pluripotent stem cells (hPSCs) have made rapid progress. Depending on questions that researchers have, hPSCs can be differentiated into specific neural cells or brain structures by culturing them in either two- or three-dimensional culture systems. In this session, speakers will introduce the cutting edge techniques of hPSC-based research in nervous system development and the beauty of the hPSC-based models of human neurodevelopmental diseases.
Time | Speaker | Affiliation | Title |
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14:20-14:45 | In-Hyun Park | Yale University | Genetic engineering of brain organoids to incorporate the vessel and immune cells |
14:45-15:10 | Woong Sun | Korea University | Dorsoventral patterning of human spinal cord organoid using micropatterning technology |
15:10-15:35 | Yong Jun Kim | Kyung Hee University | Role of m6A RNA modification in the early development of peripheral nervous system |
15:35-16:00 | Jinju Han | Korea Advanced Institute of Science and Technology | AGO1 affects social behaviors by shaping brain structure |
Daewoo Lee (Ohio University)
In-Hyun Park (Yale University)
ModeratorDoo-Sup Choi (Mayo Clinic College of Medicine and Science)
Supported by Korea Mouse Phenotyping Center
At the AKN (Association of Korean Neuroscientists in the United States) session, four outstanding investigators will share their most recent research outcomes on neurological diseases. Our speakers will cover the topics including pain, schzophenia, addiction and ischemia. Audience who are interested in cutting-edge tools including neuroimaging, molecular systems biology and stem cells, will have a great chance to learn from these leading experts and also interact with them to further discuss their research topics.
Time | Speaker | Affiliation | Title |
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9:00-9:25 | Yu Shin Kim | University of Texas Health Science Center at San Antonio | Mast cell-specific receptor mediates alcohol withdrawal-associated headache |
9:25-9:50 | Hyunsoo Shawn Je | Duke-NUS Medical School | Modeling parkinson’s disease using human midbrain-like organoids |
9:50-10:15 | Doo-Sup Choi | Mayo Clinic | Neuroscience of breaking the bad habits: molecular and computational approaches focusing on striatum-pallidal circuits |
10:15-10:40 | Sunghee Cho | Weill Cornell Medicine | Neuroimmune interaction in experimental cerebral ischemia: CNS vs peripheral immunity |
Hyungju Park (Korea Brain Research Institute)
ModeratorKyoungho Suk (Kyungpook National University)
Growing evidence has supported an idea that glial cells are important players for regulating brain functions. Astrocyte, which is the major population of glial cells, regulates neural circuits in normal or diseased brains, by releasing substances and cytokines, modifying brain structures, or enhancing cell survivals and differentiation. This scientific session will cover recent findings on how astrocytic mechanisms are implicated in controlling brain functions.
Time | Speaker | Affiliation | Title |
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9:00-9:25 | Jun Nagai | Riken | Exploring astrocyte roles in top-down regulation of behavior |
9:25-9:50 | Wuhyun Koh | Institute for Basic Science | Astrocytes render memory flexibility by releasing D-serine and regulating NMDA receptor tone in the hippocampus |
9:50-10:15 | Jinsoo Seo | Daegu Gyeongbuk Institute of Science and Technology | ApoE4 alters inflammatory response in astrocytes |
10:15-10:40 | Mi-Yoon Chang | Hanyang University | Therapeutic function of astrocyte to treat neurodegenerative disease |
Yong-Seok Lee (Seoul National University)
Keiko Tanaka-Yamamoto (Korea Institute of Science and Technology)
ModeratorYong-Seok Lee (Seoul National University)
The cerebellum is well known for its roles in motor coordination and motor-based learning. However, it is also widely involved in a diverse range of non-motor functions such as reward, social, emotion and sensor perceptions. Accordingly, cerebellar dysfunctions are associated with many brain disorders from autism spectrum disorders to. In this symposium, we will discuss new perspectives on the cerebellar functions, mainly focused but not limited to the non-motor cognitive functions based on new findings from the speakers’ laboratories.
Time | Speaker | Affiliation | Title |
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9:00-9:25 | Keiko Tanaka-Yamamoto | Korea Institute of Science and Technology | VTA-projecting cerebellar neurons mediate stress-dependent depression-like behavior |
9:25-9:50 | Sang Jeong Kim | Seoul National University | Glia-mediated cerebellar pain modulation |
9:50-10:15 | Yong-Seok Lee | Seoul National University | Cerebellar output network regulating classical fear conditioning |
10:15-10:40 | Gen Ohtsuki | Kyoto University | Immune-triggered excitability plasticity and psychiatric disease models |
Kihoon Han (Korea University)
Myungjin Kim (Korea Brain Research Institute)
ModeratorKihoon Han (Korea University)
Myungjin Kim (Korea Brain Research Institute)
The Young investigators symposium is organized specifically for young scientists who are PhD students, postdoctoral fellows, and junior PIs within the field of neuroscience. The scientific program committee will review all abstracts submitted under the oral category and select 8 to 10 abstracts to be presented. This symposium will give young neuroscientists with a bright future opportunities to present and discuss their research results and start to broaden their network in the field.
Suk-Ho Lee (Seoul National University)
ModeratorSuk-Ho Lee (Seoul National University)
Memory is thought to be represented by neuronal ensembles and stored as engram, and synaptic plasticity is one of key underlying mechanisms responsible for the formation of memory engram. The memory engram undergoes modification not only during repetitive learning but also offline state. In this symposium, the speakers will talk about the novel cellular mechanisms underlying excitatory synapses on interneurons, synaptic correlates of memory engram, reformation and interactions of engrams over days of learning.
Time | Speaker | Affiliation | Title |
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14:10-14:35 | Huan Ma | Zhejiang University | Rational designing of oscillatory rhythmicity for memory rescue in plasticity-impaired learning networks |
14:35-15:00 | Kaoru Inoguchi | University of Toyama | Functional roles of the Idling brain: from memory engram to behavior |
15:00-15:25 | Bong-Kiun Kaang | Seoul National University | Synaptic correlates of associative fear memory in the lateral amygdala |
15:25-15:50 | Suk-Ho Lee | Seoul National University | Incremental decorrelation of CA3 ensembles associated with contextual discrimination learning |
Eunjoon Kim (Korea Advanced Institute of Science and Technology)
Eunee Lee (Yonsei University)
ModeratorEunjoon Kim (Korea Advanced Institute of Science and Technology)
Eunee Lee (Yonsei University)
Supported by Institute for Basic Science Center for Synaptic Brain Dysfunctions
Autism spectrum disorders (ASD) represent a neurodevelopmental disorder characterized by social deficits and repetitive behaviors. In addition, ASD accompanies various neurodevelopmental dysfunctions, including intellectual disability, anxiety, ADHD-like hyperactivity, epilepsy, and sensory hypersensitivity. However, the mechanisms underlying ASD such as synaptic, neuronal, and circuit mechanisms are not well understood. The speakers in this session will discuss various aspects of ASD mechanisms ranging from neural correlates of social interaction and synaptic, neuronal, and circuit dysfunctions in ASD.
Time | Speaker | Affiliation | Title |
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14:10-14:35 | Weizhe Hong | University of California, Los Angeles | Neural circuit mechanisms of prosocial behavior |
14:35-15:00 | Toru Takumi | Kobe University | Towards understanding the pathophysiology of autism using models |
15:00-15:25 | Albert Basson | Kings College London | Chromatin dysregulation in Autism Spectrum and Intellectual Disability Disorders |
15:25-15:50 | Eunee Lee | Yonsei University | Reduced social information coding in the mPFC of animal models of autism |
Jinhyun Kim (Korea Institute of Science and Technology)
Seok-Kyu Kwon (Korea Institute of Science and Technology)
ModeratorJinhyun Kim (Korea Institute of Science and Technology)
Seok-Kyu Kwon (Korea Institute of Science and Technology)
Supported by Korea Institute of Science and Technology Brain Science Institute
The field of brain science is dramatically advanced during past decade with global investment by government-driven programs such as the BRAIN Initiative. Alongside this achievement, enhanced computing power and accumulated biological data allow the artificial intelligence (AI) to expedites novel findings in neuroscience. However, compared to general intelligence, AI still has limitation to solve arbitrary problems with high energy efficiency. To overcome this hurdle, researchers implant various neural network models to the AI. In this symposium, we will discuss how strengthened relationship between AI and neural circuit paves the way to study neurobiology, computational neuroscience, and neuroimaging.
Time | Speaker | Affiliation | Title |
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14:10-14:35 | Yuji Ikegaya | University of Tokyo | AI-boosted cognitive performance of rats |
14:35-15:00 | Jeehyun Kwag | Korea University | GABAergic interneuron dysfunction in Alzheimer’s disease: Implications for treatments and insights into learning rules |
15:00-15:25 | Choongwan Woo | Sungkyunkwan University | Homeostasis: A key to understanding the brain dynamics and intelligenc |
15:25-15:50 | Hyungju Jeon | Korea Institute of Science and Technology | Spatiotemporal dynamics of functional clusters in basal ganglia neural circuits |
Young Soo Kim (Yonsei University)
Seung-Hoon Yang (Dongguk University)
ModeratorYoung Soo Kim (Yonsei University)
Supported by Korea Dementia Research Center
This symposium is organized and lectured by investigators of Korea Dementia Research Center supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare and Ministry of Science and ICT.
Time | Speaker | Affiliation | Title |
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14:10-14:35 | Sungsu Lim | Korea Institute of Science and Technology | Visualization of soluble tau oligomers in the brain of TauP301L-BiFC transgenic mice reveals consequential events of tau aggregation |
14:35-15:00 | Jinmyoung Joo | Ulsan National Institute of Science and Technology | Tailored surface functionalization of porous nanoparticles for enhanced neuronal uptake |
15:00-15:25 | Seung-Hoon Yang | Dongguk University | AD therapeutic effects of Fucoxanthin from microalgae Phaeodactylum tricornutum by both regulating neuroinflammatory signaling and amyloid protein misfolding |
15:25-15:50 | Zee Yong Park | Gwangju Institute of Science and Technology | Blood based early diagnosis of neurodegenerative diseases by LC-MS |
Seog Bae Oh (Seoul National University)
ModeratorSeog Bae Oh (Seoul National University)
Sun Wook Hwang (Korea Univesity)
The Nobel Prize in Physiology/Medicine 2021 was awarded jointly to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch.” David Julius discovered TRPV1 as an ion channel activated by heat and capsaicin in sensory neurons and TRPV1 is also critically involved in pathological pain. Ardem Patapoutian discovered Piezo2 as a mechanosensitive ion channel for touch, and Piezo2 can be a potential molecular target for mechanical allodynia, pain evoked by non-painful mechanical stimuli. The symposium is organized to celebrate this year’s Nobel prize in Physiology/Medicine, and speakers will present their recent works in pain field.
Time | Speaker | Affiliation | Title |
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16:00-16:25 | Xu Zhang | Chinese Academy of Sciences | Central neural networks for nociception and itch |
16:25-16:50 | Makoto Tominaga | National Institute for Physiological Sciences | Nociception through TRP channels |
16:50-17:15 | Seog Bae Oh | Seoul National University | Transcriptional profiling of dental primary afferent neurons by single-cell RNA sequencing |
17:15-17:40 | Yong Ho Kim | Gachon University | Amyloid-beta 1-42 alleviates TRPV1-dependent pain via LRP1-SHP2 pathway |
Inah Lee (Seoul National University)
Suk-Ho Lee (Seoul National University)
ModeratorSuk-Ho Lee (Seoul National University)
Inah Lee (Seoul National University)
Decision making relies on complex cognitive processes and its underlying neural mechanisms are largely unknown. In the brain, one of the major players in decision making is the prefrontal cortex and its associated neural networks. Various subregions of the prefrontal cortex exhibit complex and dynamic functional connectivities with other brain areas to make effective decision-making possible in various contexts. Speakers of the current symposium will present their latest experimental results about this topic to share their insights on the prefrontal cortical mechanisms of decision making and how animals guide their future behavior based on their past experience.
Time | Speaker | Affiliation | Title |
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16:00-16:25 | Inah Lee | Seoul National University | The hippocampal-dependent, temporal organization of the neural firing patterns in the prefrontal cortex in a visual working memory task |
16:25-16:50 | Min Whan Jung | Korea Advanced Institute of Science and Technology | Division of labor among different types of prefrontal cortical neurons |
16:50-17:15 | Seung-Hee Lee | Korea Advanced Institute of Science and Technology | Gated feedforward inhibition in the frontal cortex triggers goal-directed action |
17:15-17:40 | Alan J. Park | Columbia University | Brain circuit reset: Principles of cognitive enhancement in health and disease |
Jeong-woo Sohn (Catholic Kwandong University)
Hyoung Kim (Seoul National University)
ModeratorJeong-woo Sohn (Catholic Kwandong University)
Technology to record a large number of neuronal unit activities have become common in system neuroscience field last decade. This change impact analytical methods how to deal with data of high computational demand. However, the impact does not stay at the level of analysis but extend to the level of seeing how our brain works. In this session, speakers from single neuronal recording paradigm to multiple recording one will present their research result and discuss the view how the brain works.
Time | Speaker | Affiliation | Title |
---|---|---|---|
16:00-16:25 | Hyoung Kim | Seoul National University | How can primates make an automatic choice? – By automatic memory retrieval in the ventral striatum of human and monkey brains |
16:25-16:50 | Camilo Libedinsky | National University of Singapore | A Dynamical Systems Approach to Neural Computations |
16:50-17:15 | Sung-Phil Kim | Ulsan National Institute of Science and Technology | Coupling of neuronal selectivity to latent space in anterior lateral motor cortex |
17:15-17:40 | Jeong-woo Sohn | Catholic Kwandong University | Neural representation of value in the latent subspace in three different cortical areas |
Jaewon Ko (Daegu Gyeongbuk Institute of Science and Technology)
ModeratorJaewon Ko (Daegu Gyeongbuk Institute of Science and Technology)
Supported by Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology
The number of studies of the mind, brain and behavior has increased markedly in recent years. The development of new tools and approaches has enabled studies addressing fundamental questions regarding brain organization and computation. This symposium highlights studies in brain and cognitive sciences that are currently ongoing at the Daegu Gyeongbuk Institute of Science and Technology (DGIST). Three scientists have been invited to present results of studies addressing specific neuroscientific questions in worms, mice and humans. In addition, Professor Sung Han will be recruited to introduce cutting-edge systems approaches to tackle one of the trending topics in modern neuroscience.
Time | Speaker | Affiliation | Title |
---|---|---|---|
16:00-16:25 | Kyuhyung Kim | Daegu Gyeongbuk Institute of Science and Technology | Mechanosensitive Piezo Channel, PEZO-1, regulates food deglutition in C. elegans |
16:25-16:50 | Hyeon-Ae Jeon | Daegu Gyeongbuk Institute of Science and Technology | High-level cognition in humans: Reasoning using bayesian meta-analysis of the cortical surface (BMACS) |
16:50-17:15 | Kwang Lee | Daegu Gyeongbuk Institute of Science and Technology | A multiplication rule for integrating corticostriatal and thalamostriatal signals |
17:15-17:40 | Han Sung | Salk Institute | Opioids and pain-breathing interaction |
Min Soo Kim (Korea Institute of Science and Technology)
Min Seon Kim (Asan Medical Center)
ModeratorMin Seon Kim (Asan Medical Center)
Min Soo Kim (Korea Institute of Science and Technology)
The dysfunction of energy homeostasis via the orchestrated action of neural pathways is a critical cause of metabolic syndrome and aging-related diseases. It has been proposed that the regulation of homeostasis helps to control aging. In this session, the regulation of homeostasis for retarding aging will be introduced.
Time | Speaker | Affiliation | Title |
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9:00-9:25 | Dongsheng Cai | Albert Einstein College of Medicine | Role of the hypothalamus for whole-body aging |
9:25-9:50 | Seung-Jae V. Lee | Korea Advanced Institute of Science and Technology | Neuroendocrine regulation of aging in C. Elegans |
9:50-10:15 | Young-Sam Lee | Daegu Gyeongbuk Institute of Science and Technology | Disruption of nucleocytoplasmic trafficking as an key feature of cellular senescence |
10:15-10:40 | Sang-Hun Lee | Hanyang University | hypothalamic neural stem/precursor cells (ht-NSCs) derived from human hypothalamus-like organoids as a stable source for hypothalamic researches and anti-aging therapy |
Young-Joon Kim (Gwangju Institute of Science and Technology)
Jae-Young Kwon (Sungkyunkwan University)
ModeratorYoung-Joon Kim (Gwangju Institute of Science and Technology)
Supported by Neurorive Inc.
Invertebrates models were seminal to our current understanding of how the brain assemble behaviors. The fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans have unparalleled genetic tools for neural circuit analysis. In 2018, a complete electron microscopy volume of the adult fly brain comprising 100,000 neurons was released. C. elegans is the first metazoan with synapse-level neural maps. Now, the high-resolution connectome combined with advanced genetic and optogenetic tools renders these invertebrates ideal for discovering neural circuits and understanding their circuit logics. This symposium demonstrates how one can address fundamental questions of behavioral neuroscience with advances in invertebrate models.
Time | Speaker | Affiliation | Title |
---|---|---|---|
9:00-9:25 | Woochan Choi | Daegu Gyeongbuk Institute of Science and Technology | A chemosensory GPCR is necessary for a concentration-dependent behavioral switching in C. elegans |
9:25-9:50 | Anmo J. Kim | Hanyang University | A concise visuomotor circuit underlies small object avoidance in flying Drosophila |
9:50-10:15 | Do-Hyung Kim | Gwangju Institute of Science and Technology | CRF-like neuropeptide signaling regulates reproductive maturation in Drosophila |
10:15-10:40 | Wei-Chung Allen Lee | Boston Children’s Hospital | Neuronal circuits enabling sensory-guided action and behavior |
Jun Soo Kwon (Seoul National University)
Minah Kim (Seoul National University Hospital)
ModeratorJun Soo Kwon (Seoul National University)
Jin-A Lee (Hannam University)
Schizophrenia is a major psychiatric disorder with marked functional decline and chronic course along with psychotic symptoms such as auditory hallucinations and delusions. Schizophrenia is regarded as a disorder of brain connectivity caused by abnormalities in neuronal migration, synaptogenesis, synaptic pruning, and myelinization. Thus, it is important to broaden our knowledge about brain connectivity of schizophrenia, from cellular to network level, in understanding schizophrenia pathophysiology and developing better treatment for patients. In this symposium, the speakers would cover the cellular to network-level connectivity of schizophrenia brain: cellular mechanism, animal model, electrophysiological connectivity, and functional connectivity.
Time | Speaker | Affiliation | Title |
---|---|---|---|
9:00-9:25 | Jin-A Lee | Hannam University | Modeling neurodevelopmental disorders using human patient specific induced pluripotent stem cell (iPSC) technology |
9:25-9:50 | Won-Suk Chung | Korea Advanced Institute of Science and Technology | Stress evokes mental disorders via astrocytic MERTK-dependent synaptic phagocytosis |
9:50-10:15 | Minah Kim | Seoul National University Hospital | Electrophysiological connectivity of schizophrenia brain |
10:15-10:40 | Shinsuke Koike | University of Tokyo | Functional connectivity of schizophrenia brain |
Choongwan Woo (Sungkyunkwan University)
Won Mok Shim (Sungkyunkwan University)
ModeratorChoongwan Woo (Sungkyunkwan University)
Dongil Chung (Ulsan National Institute of Science and Technology)
"Where does value come from?" This question is central to the understanding of our natural intelligence and how we can build better artificial intelligence agents. In this symposium, we will explore answers to the question by examining how values are formed, represented, and computed in naturalistic and social environments through the lens of cognitive neuroscience and artificial intelligence.
Time | Speaker | Affiliation | Title |
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9:00-9:25 | Won Mok Shim | Sungkyunkwan University | Representations of value in naturalistic tasks |
9:25-9:50 | Jee Hang Lee | Sangmyung University | The role of intrinsic values in the normative decision making of artificial agents |
9:50-10:15 | Seongmin A. Park | University of California, Davis | The geometry of cognitive maps under dynamic cognitive control |
10:15-10:40 | Dongil Chung | Ulsan National Institute of Science and Technology | Impacts of feature-based value generalization on learning |